Novel Drug Delivery System
Drug delivery is the process of administering the drug or pharmaceutical product, in order to achieve the desired therapeutic effect. The method by which drug delivered is important, as it has a significant effect on its efficacy. Novel drug delivery system involves various approaches like medical devices or drug-device combination products. Novel drug delivery system (NDDS) involves combining polymer science, pharmaceutics and molecular biology.
To minimize drug degradation and loss to prevent harmful side-effects and to increase drug bioavailability and the fraction of the drug accumulated in the required zone, various drug delivery and drug targeting systems are currently under development. Among drug carriers one can name soluble polymers,micro particles made of insoluble or biodegradable natural and synthetic polymers, microcapsules, cells, cell ghosts, lipoproteins, liposomes, and micelles. The carriers can be made slowly degradable, stimuli-reactive (e.g., pH- or temperature-sensitive), and even targeted (e.g., by conjugating them with specific antibodies against certain characteristic components of the area of interest). Targeting is the ability to direct the drug-loaded system to the site of interest. Two major mechanisms can be distinguished for addressing the desired sites for drug release: (i) passive (ii) active targeting.